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[4] In other words, most patients with detectable anti-sermorelin antibodies continue to respond to therapy, and the antibodies may disappear over time even if treatment continues

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Studies of global IGF-I KO mice (50,51), which survive to adulthood, show decreased bone formation rates, but higher trabecular bone mass (BV/TV), indicating reduction in both osteogenic and osteoclastogenic activities in the bones

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